Weakly supervised segmentation of COVID-19 infection with local lesion coherence on CT imagesResearch article Published on 2023-01-012022-10-05 Journal: Biomedical Signal Processing and Control [Category] 진단, 치료기술, [키워드] absence Accuracy Algorithm approach Attention automated chain Characteristics Clinical diagnosis Complete complex Computed tomography COVID-19 COVID-19 infection CT scan dataset deep learning diagnostic edge effective expression gold standard help IMPROVE individual information labeling labor-intensive lesion Local Local Coherence Lung infection module Novel coronavirus offer overcome public health reaction Region RT-PCR scale seeking Segmentation severity the disease time-consuming Weakly Supervised [DOI] 10.1016/j.bspc.2022.104099 [Article Type] Research article
Research progress of biosensors for detection of SARS-CoV-2 variants based on ACE2Article Published on 2023-01-012022-11-15 Journal: Talanta [Category] SARS, 변종, 치료기술, [키워드] Accuracy ACE2 acute respiratory syndrome addition antibody biosensor biosensors caused Cell cells complex coronavirus coronavirus disease COVID-19 detect detection Diagnosis drug evaluated gold standard Health increase Interaction modulate Mutation Novel coronavirus pandemic Prevent receptor RT-PCR SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2. the spike protein time-consuming variants Variation virus virus mutations [DOI] 10.1016/j.talanta.2022.123813 PMC 바로가기
Application of a high-throughput quantitative PCR system for simultaneous monitoring of SARS-CoV-2 variants and other pathogenic viruses in wastewaterArticle Published on 2022-12-202022-11-15 Journal: The Science of the total environment [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료제, [키워드] acute respiratory syndrome Alpha variant analyzed application applied assays can be used collected Community coronavirus coronavirus disease COVID-19 delta variant demonstrated detect eight epidemiologically FIVE Health High-throughput qPCR highlighting increase Japan L452R labor-intensive likelihood Mie N501Y nine nucleotide nucleotide substitution pathogenic virus pathogenic viruses Pathogenic viruses, SARS-CoV-2 Patient PCR positive prevalent qPCR quantitative PCR quarantine reported RNA RT-qPCR SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 variant separated Surveillance target tested time-consuming Treatment virus viruses Volume wastewater Wastewater. Yokkaichi [DOI] 10.1016/j.scitotenv.2022.158659 PMC 바로가기
Sensitive detection of SARS-CoV-2 molecular markers in urban community sewersheds using automated viral RNA purification and digital droplet PCRArticle Published on 2022-11-152022-11-15 Journal: The Science of the total environment [Category] COVID19(2023년), SARS, 바이오마커, 치료기술, [키워드] affecting approach automated Care Community correlation COVID-19 COVID-19 case detection of marker Detroit disadvantage Effectiveness Epidemiology faster Final handling Health identify inhibitor Local marker molecular number of sample outbreak PCR PerkinElmer Prevent Promega public health authority purification required RNA RNA purification SARS-CoV-2 sensitive sensitivity Standard state the SARS-CoV-2 virus Thermofisher time-consuming Viral RNA Volume wastewater Wastewater. [DOI] 10.1016/j.scitotenv.2022.157547 PMC 바로가기
Development of multiplex S-gene-targeted RT-PCR for rapid identification of SARS-CoV-2 variants by extended S-gene target failureArticle Published on 2022-11-012022-11-15 Journal: Clinica chimica acta; international journal of cli [Category] SARS, 변종, 치료기술, 치료제, [키워드] binding caused codon concordance rate Delta development Epidemics genomic sequencing Internal control Japan multiplex Multiplex RT-PCR Mutation N-gene omicron probe Rapid Rapid screening Region RT-PCR S-gene S-gene mutations S-gene target failure SARS-CoV-2 SARS-CoV-2 variant screening method Sequencing time-consuming Variant of concern. VoC VOCs [DOI] 10.1016/j.cca.2022.08.031 PMC 바로가기
Modular nanoarray vaccine for SARS-CoV-2Article Published on 2022-11-012022-11-15 Journal: Nanomedicine : nanotechnology, biology, and medici [Category] SARS, 변종, 진단, [키워드] B-cell epitope children complementary COVID-19 pandemic defined delta variant DNA effective epitope generate Gold nanoparticle IgG immune response immunized immunocompromised individuals immunogen immunogenic inactive mice mRNA neutralizing antibody PADRE peptide pregnant women probe recombinant proteins resulting SARS-CoV-2 spike glycoprotein time-consuming Vaccine Vaccine development vaccine platform Variants of concerns (VOC). virus neutralizing titer virus-like particles viruses VoC while wildtype [DOI] 10.1016/j.nano.2022.102604 PMC 바로가기
A review on computer-aided chemogenomics and drug repositioning for rational COVID-19 drug discoveryArticle Published on 2022-11-012022-11-15 Journal: Chemical biology & drug design [Category] 변종, 신약개발, 치료기술, 치료제, [키워드] analyzed application assist chemogenomics compounds Computational drug computational drug discovery Computational methods coronavirus coronavirus disease CoV COVID-19 CoVs drug candidate Drug discovery drug repositioning drugs Efficiency epidemic diseases example feasible Host in silico approaches molecular docking other variants outcome Polypharmacology polypharmacology. Protein provide reflected reported Spread therapeutic target time-consuming Toxicity turn unique virus virus [DOI] 10.1111/cbdd.14136 PMC 바로가기
Case report: BA.1 subvariant showing a BA.2-like pattern using a variant-specific PCR assay due to a single point mutation downstream the spike 69/70 deletionArticle Published on 2022-10-272022-11-15 Journal: Virology Journal [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료제, [키워드] Accuracy Algorithm Amino acid amplification BA.1 BA.4 BA.5 Cluster COVID-19 pandemic database detect diagnostic downstream epidemiological example faster genomic knowledge melting curve analysis Mutation mutations next generation sequencing Next-generation sequencing NGS omicron over overcome PCR PCR assay Point mutation probe SARS-CoV-2 SARS-CoV-2 variant sequence Spain specific mutation Surveillance temperature time-consuming variant Variant-specific PCR. while [DOI] 10.1186/s12985-022-01883-2 PMC 바로가기
Utilization of the Abbott SARS-CoV-2 IgG II Quant Assay To Identify High-Titer Anti-SARS-CoV-2 Neutralizing Plasma against Wild-Type and Variant SARS-CoV-2 VirusesArticle Published on 2022-10-262022-11-15 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] 95% confidence interval Abbott Abbott SARS-CoV-2 IgG acute respiratory syndrome Analysis approach approach authorization BAU Beta binding antibody unit Canada CCP characterized Chicago Chicago IL clinical trial convalescent convalescent plasma coronavirus COVID-19 COVID-19 convalescent plasma Cutoff Delta disease course drug Emergency EUA evaluated Evidence experiment FDA food Gamma highest hospitalized patient Humoral immunity identify IgG immune IMPROVE Mann-Whitney U method comparisons Neutralization assay Neutralizing neutralizing antibody outcome Patient patient group plaque reduction neutralization plaque reduction neutralization. plasma PRNT quantitative determination required SARS-CoV-2 SARS-CoV-2 antibody selected significantly specimen tested the SARS-CoV-2 time-consuming treat United State utilization variant VLP VoC wild-type with COVID-19 [DOI] 10.1128/spectrum.02811-22 PMC 바로가기
Advances in Biosensing Technologies for Diagnosis of COVID-19Article Published on 2022-10-202022-11-15 Journal: Biosensors [Category] COVID19(2023년), SARS, 치료기술, [키워드] advance Biomarker biosensor biosensors. carrier Community contagiousness COVID-19 COVID-19 biomarkers COVID-19 diagnosis COVID-19 pandemic Diagnosis diagnosis of COVID-19 Diagnostic biomarkers diagnostic test diagnostics Disadvantages high mortality immune response impacted Infection Major number of sample pathogenesis of COVID-19 point-of-care proinflammatory provide Research RT-qPCR SARS-CoV-2 specimen Spread technology time-consuming traditional method viral genomes Viral proteins [DOI] 10.3390/bios12100898 PMC 바로가기